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A thousand times no! 绝对办不到！

Don't mention it. 没关系，别客气。

Who knows! 天晓得！

It is not a big deal! 没什么了不起！

How come… 怎么回事，怎么搞的。 （很常用，可以用在发牢骚、抱怨、意外等语境）

Easy does it. 慢慢来。

Don't push me. 别逼我。

Come on! 快点，振作起来！

Have a good of it. 玩得很高兴。（口语很少用Have a good time)

It is urgent. 有急事。

What is the fuss？ 吵什么？

Still up？ 还没睡呀？

It doesn't make any differences. 没关系。

Don't let me down. 别让我失望。

God works. 上帝的安排。

Don't take ill of me. 别生我气。 （注意，这里用了take ill of）

Go down to business. 言归正传。

None of my business. 不关我事。

It doesn't work. 不管用。

I'm not going. 我不去了。

Does it serve your purpose？ 对你有用吗？

I don't care. 我不在乎。

Not so bad. 不错。

No way! 不可能！

Don't flatter me. 过奖了。

Your are welcome. 你太客气了

Hope so. 希望如此。